Gp130通过STAT3-JAK2途径促进过敏性结膜炎炎症
核心信息
- 论文英文标题: Gp130 Promotes Inflammation via the STAT3/JAK2 Pathway in Allergic Conjunctivitis
- 期刊: INVEST OPHTH VIS SCI
- 发表年份: 2023
- DOI: 10.1167/iovs.64.4.5
- PMID/PMCID: 37022703; PMC10082384
研究概览
We found that gp130 is essential for AC, as gp130 levels are elevated in AC. Inhibiting gp130 phosphorylation alleviates ocular surface inflammation in mice, presenting a potential treatment approach for AC.
核心发现
Gp130 is upregulated in the conjunctival tissues of OVA-induced mice, the serum and tears of patients, and the histamine-stimulated HConEpiCs.
Signal transducer and activator of transcription 3 (STAT3) and Janus kinase 2 (JAK2) were upregulated in the conjunctival tissues of mice with OVA-induced AC and in HConEpiCs.
Ocular surface inflammation was significantly relieved in LMT-28-treated mice.
The expression of IgE, IL-4, IL-5, and IL-13 in serum of LMT-28-treated mice decreased.
研究设计
To compare mRNA expression profiles, the conjunctival tissues of BALB/c mice with ovalbumin (OVA)-induced AC were subjected to RNA-sequencing (RNA-seq) analysis followed by bioinformatic analysis.
A nonrandomized study involving 57 patients with AC and 24 sex- and age-matched healthy individuals was conducted.
A protein chip was used to detect cytokine levels in patient tears.
Echo Biotech 角色
结膜组织普通转录组测序分析
关联平台: Exoomics®
关联服务与能力: EV Whole-Transcriptome Sequencing
关联产品或试剂: 无明确产品引用
参考文献
原始论文: Gp130 Promotes Inflammation via the STAT3/JAK2 Pathway in Allergic Conjunctivitis Investigative ophthalmology & visual science. 2023. DOI: 10.1167/iovs.64.4.5. PMID/PMCID: 37022703; PMC10082384.