利用肌肉组织来源富含线粒体的EVs（Ti-mitoEVs）促进线粒体生物发生以推动再生医学的发展
核心信息
- 论文英文标题: Harnessing tissue-derived mitochondria-rich extracellular vesicles (Ti-mitoEVs) to boost mitochondrial biogenesis for regenerative medicine
- 期刊: Sci Adv
- 发表年份: 2025
- DOI: 10.1126/sciadv.adt1318
- PMID/PMCID: 40668934; PMC12266123
研究概览
This study highlights the promising role of Ti-mitoEVs in boosting mitochondrial biogenesis, positioning them as potential therapies for treating various types of tissue injury characterized by mitochondrial damage. Inspired by the natural role of extracellular vesicles (EVs) in regulating mitochondrial metabolism, we report that healthy tissue-derived mitochondria-rich EVs (Ti-mitoEVs) can boost mitochondrial biogenesis for regenerative medicine.
核心发现
Mitochondrial damage is a critical pathological factor in various forms of tissue injury, and specific therapies with high biosafety are desirable.
Inspired by the natural role of extracellular vesicles (EVs) in regulating mitochondrial metabolism, we report that healthy tissue-derived mitochondria-rich EVs (Ti-mitoEVs) can boost mitochondrial biogenesis for regenerative medicine.
Ti-mitoEVs that contain abundant functional mitochondria can be highly efficiently isolated from muscles via an optimized method.
In vitro, Ti-mitoEV treatment increased mitochondrial biogenesis and reduced mitochondrial damage in recipient cells, and these effects occurred at least partly via mitochondrial genome transfer.
Echo Biotech 角色
Exosupur®排阻柱以提高超离UC分离的组织EV纯度
关联平台: Exoomics®, Research Reagents & Tools
关联服务与能力: Tissue EV Isolation & Purification, EV Quality Analytics, Research Reagent / Product Supply
关联产品或试剂: Exosupur® EV Isolation/Purification Kit
参考文献
原始论文: Harnessing tissue-derived mitochondria-rich extracellular vesicles (Ti-mitoEVs) to boost mitochondrial biogenesis for regenerative medicine Science advances. 2025. DOI: 10.1126/sciadv.adt1318. PMID/PMCID: 40668934; PMC12266123.