热应激通过EVs介导的潜在瘤胃-乳腺通信抑制泌乳：微生物组、代谢组和miRNA谱的综合分析

核心信息

  • 论文英文标题: Heat stress suppresses lactation through potential rumen-mammary communication mediated by extracellular vesicles: integrated analysis of microbiome, metabolome, and miRNA profiles
  • 期刊: Microbiome
  • 发表年份: 2026
  • DOI: 10.1186/s40168-026-02363-3
  • PMID/PMCID: 41845494; PMC13107730

研究概览

This study aimed to elucidate how HS suppresses lactation through potential rumen-mammary communication mediated by EVs, using a comprehensive multi-omics approach. This study demonstrates that HS suppresses lactation through multi-level alterations in the rumen microbiome, metabolic homeostasis, and EV-derived miRNA signaling, collectively supporting the existence of a potential rumen-mammary communication axis.

核心发现

Dairy cows exposed to HS exhibited elevated rectal temperatures and respiratory rates, accompanied by significant reductions in the yield of milk, milk fat and protein.

Rumen fermentation was markedly impaired, with decreased pH, butyrate, and valerate proportions, and systemic inflammation was evidenced by increased pro-inflammatory cytokines and barrier dysfunction.

Metagenomic profiling revealed that HS reshaped the rumen microbiome, significantly reducing the relative abundances of Prevotella, Bifidobacterium, and Lactobacillus species while enriching methanogenic and low-efficiency fermentative taxa.

Functionally, HS enhanced microbial methane metabolism and suppressed carbohydrate degradation pathways, reducing the host's energy supply for milk synthesis.

Echo Biotech 角色

奶牛血浆外泌体和乳汁(牛奶)外泌体分离鉴定&miRNA测序分析(引用试剂盒Exosupur ES9P11e)

关联平台: Exoomics®, Research Reagents & Tools

关联服务与能力: Biofluid EV Isolation & Purification, EV Basic Characterization (TEM/NTA/WB), EV miRNA Profiling / Sequencing, Research Reagent / Product Supply

关联产品或试剂: Exosupur® EV Isolation/Purification Kit

参考文献

原始论文: Heat stress suppresses lactation through potential rumen-mammary communication mediated by extracellular vesicles: integrated analysis of microbiome, metabolome, and miRNA profiles Microbiome. 2026. DOI: 10.1186/s40168-026-02363-3. PMID/PMCID: 41845494; PMC13107730.