通过外泌体miRNA识别高危多发性骨髓瘤并预测预后
核心信息
- 论文英文标题: Identification and prognostic prediction of high-risk multiple myeloma by exosomal microRNA
- 期刊: Front Oncol
- 发表年份: 2025
- DOI: 10.3389/fonc.2025.1659708
- PMID/PMCID: 41244896; PMC12615177
研究概览
The study prospectively collected plasma samples and clinical data of newly diagnosed multiple myeloma (NDMM) patients and healthy controls (HCs). This project establishes a plasma exosomal miRNA-based system for diagnosing multiple myeloma(MM) and evaluating patient prognosis, aiming to provide novel strategies for diagnosis and early warning in high-risk MM patients.
核心发现
In a validation cohort of 130 MM patients, we developed a prognostic nomogram that amalgamated the expression levels of three key exosomal miRNAs (hsa-miR-193b-5p, miR-483-3p, and let-7b-5p) with critical clinical variables, which exhibits superior performance compared to the ISS staging system.
This integrative model effectively predicted 1-, 3-, and 5-year survival probabilities, thereby stratifying patients into distinct risk categories for enhanced clinical decision-making and personalized follow-up strategies.
研究设计
The study prospectively collected plasma samples and clinical data of newly diagnosed multiple myeloma (NDMM) patients and healthy controls (HCs).
Plasma samples were obtained in MM patients before the administration of any chemotherapy.
The study comprises three stages to identify plasma exosomal miRNAs associated with the diagnosis and prognosis of MM.
Echo Biotech 角色
血浆外泌体分离表征&外泌体miRNA测序分析&qPCR验证
关联平台: Exoomics®, Research Reagents & Tools
关联服务与能力: Biofluid EV Isolation & Purification, EV Basic Characterization (TEM/NTA/WB), EV miRNA Profiling / Sequencing, qPCR Validation, Research Reagent / Product Supply
关联产品或试剂: Exosupur® EV Isolation/Purification Kit
参考文献
原始论文: Identification and prognostic prediction of high-risk multiple myeloma by exosomal microRNA Frontiers in oncology. 2025. DOI: 10.3389/fonc.2025.1659708. PMID/PMCID: 41244896; PMC12615177.