鉴定唾液外泌体miRNA作为炎症性肠病非侵入性诊断和主动监测的潜在生物标志物

核心信息

• 论文英文标题: Identification of Salivary Exosome-Derived miRNAs as Potential Biomarkers for Non-Invasive Diagnosis and Proactive Monitoring of Inflammatory Bowel Disease
• 期刊: Int J Mol Sci
• 发表年份: 2025
• DOI: 10.3390/ijms26167750
• PMID/PMCID: 40869073; PMC12386383

研究概览

This study explored salivary exosomal miRNAs as potential biomarkers to address this unmet clinical need. These findings reveal dynamic associations between salivary exosomal miRNA signatures and IBD progression, underscoring their utility as non-invasive diagnostic tools.

核心发现

Inflammatory bowel disease (IBD), a chronic inflammatory disorder with relapsing/remitting characteristics, lacks reliable non-invasive biomarkers for accurate diagnosis and longitudinal monitoring.

This study explored salivary exosomal miRNAs as potential biomarkers to address this unmet clinical need.

Using discovery (24 IBD patients [11 active, 13 remission] and 6 healthy controls [HCs]) and validation cohorts (102 IBD patients [53 active, 49 remission] and 18 HCs), we analyzed miRNA profiles via reverse transcription quantitative PCR (RT-qPCR).

Receiver operating characteristic (ROC) curves evaluated diagnostic performance, with area under the curve (AUC) quantifying discriminatory capacity.

Echo Biotech 角色

唾液外泌体分离鉴定&miRNA测序分析&qPCR验证

关联平台: Exoomics®, Research Reagents & Tools

关联服务与能力: EV Isolation & Purification, EV Basic Characterization (TEM/NTA/WB), EV miRNA Profiling / Sequencing, qPCR Validation, Research Reagent / Product Supply

关联产品或试剂: Exosupur® EV Isolation/Purification Kit

参考文献

原始论文: Identification of Salivary Exosome-Derived miRNAs as Potential Biomarkers for Non-Invasive Diagnosis and Proactive Monitoring of Inflammatory Bowel Disease Journal of Entomological Science. 2025. DOI: 10.3390/ijms26167750. PMID/PMCID: 40869073; PMC12386383.