装载STING激动剂表面表达PD-L1抗体的可吸入纳米囊泡增强CAR-T细胞对肺部实体瘤的活性

核心信息

• 论文英文标题: Inhalable nanovesicles loaded with a STING agonist enhance CAR-T cell activity against solid tumors in the lung
• 期刊: Nat Commun
• 发表年份: 2025
• DOI: 10.1038/s41467-024-55751-4
• PMID/PMCID: 39747173; PMC11695690

研究概览

Suppression of chimeric antigen receptor-modified T (CAR-T) cells by the immunosuppressive tumor microenvironment remains a major barrier to their efficacy against solid tumors. To address this, we develop an anti-PD-L1-expressing nanovesicle loaded with the STING agonist cGAMP (aPD-L1 NVs@cGAMP) to remodel the tumor microenvironment and thereby enhance CAR-T cell activity.

核心发现

Suppression of chimeric antigen receptor-modified T (CAR-T) cells by the immunosuppressive tumor microenvironment remains a major barrier to their efficacy against solid tumors.

To address this, we develop an anti-PD-L1-expressing nanovesicle loaded with the STING agonist cGAMP (aPD-L1 NVs@cGAMP) to remodel the tumor microenvironment and thereby enhance CAR-T cell activity.

Following pulmonary delivery, the nanovesicles rapidly accumulate in the lung and selectively deliver STING agonists to PD-L1-overexpressing cells via the PD-1/PD-L1 interaction.

This targeted delivery effectively avoids the systemic inflammation and poor cellular uptake that plague free STING agonists.

Echo Biotech 角色

293T细胞上清外泌体分离电镜表征

关联平台: Exoomics®

关联服务与能力: Cell-Culture Supernatant EV Isolation & Purification, EV Basic Characterization (TEM/NTA/WB)

关联产品或试剂: 无明确产品引用

参考文献

原始论文: Inhalable nanovesicles loaded with a STING agonist enhance CAR-T cell activity against solid tumors in the lung Nature communications. 2025. DOI: 10.1038/s41467-024-55751-4. PMID/PMCID: 39747173; PMC11695690.