血浆外泌体lncRNA和mRNA表达谱的综合分析揭示lnc-MKRN2-42:1参与帕金森病的发病机制
核心信息
- 论文英文标题: Integrated analysis of exosomal lncRNA and mRNA expression profiles reveals the involvement of lnc-MKRN2-42:1 in the pathogenesis of Parkinson's disease
- 期刊: CNS Neurosci Ther
- 发表年份: 2020
- DOI: 10.1111/cns.13277
- PMID/PMCID: 31814304; PMC7163584
研究概览
To study expression differences for lncRNAs in peripheral blood exosomes of PD patients compared with healthy individuals and to look for lncRNAs that might be related to the pathogenesis of PD. Our study suggested that lnc-MKRN2-42:1 may be involved in the occurrence and development of PD.
核心发现
We found 15 upregulated and 24 downregulated exosomal lncRNAs in the PD group.
According to bioinformatics analyses, we chose lnc-MKRN2-42:1 for further study.
Interestingly, lnc-MKRN2-42:1 was positively correlated with the MDS-UPDRS III score for PD patients.
研究设计
We recruited PD patients along with age- and sex-matched healthy individuals as healthy controls and evaluated levels of lncRNAs extracted from exosomes in plasma samples via next-generation sequencing and real-time quantitative PCR.
Correlation analysis was conducted for the clinical characteristics of PD patients and the expression of selected lncRNAs.
Echo Biotech 角色
血浆外泌体长链RNA测序分析
关联平台: Exoomics®
关联服务与能力: EV lncRNA/mRNA Sequencing
关联产品或试剂: 无明确产品引用
参考文献
原始论文: Integrated analysis of exosomal lncRNA and mRNA expression profiles reveals the involvement of lnc-MKRN2-42:1 in the pathogenesis of Parkinson's disease CNS Neurosci Ther. 2020. DOI: 10.1111/cns.13277. PMID/PMCID: 31814304; PMC7163584.