整合转录组学、蛋白质组学和功能分析以表征乳腺癌组织特异性细胞外囊泡网络
核心信息
- 论文英文标题: Integrated transcriptomics, proteomics, and functional analysis to characterize the tissue-specific small extracellular vesicle network of breast cancer
- 期刊: MedComm
- 发表年份: 2023
- DOI: 10.1002/mco2.433
- PMID/PMCID: 38053815; PMC10694390
研究概览
We identified the actual cancer-specific sEV signatures characterized by enriched cell adhesion and immunomodulatory molecules. This study provides valuable insights into the functional characteristics of tumor tissue-derived sEVs, highlighting their potential as diagnostic markers and therapeutic agents for breast cancer.
核心发现
Small extracellular vesicles (sEVs) are essential mediators of intercellular communication within the tumor microenvironment (TME).
Although the biological features of sEVs have been characterized based on in vitro culture models, recent evidence indicates significant differences between sEVs derived from tissue and those derived from in vitro models in terms of both content and biological function.
However, comprehensive comparisons and functional analyses are still limited.
Here, we collected sEVs from breast cancer tissues (T-sEVs), paired normal tissues (N-sEVs), corresponding plasma (B-sEVs), and tumor organoids (O-sEVs) to characterize their transcriptomic and proteomic profiles.
Echo Biotech 角色
组织外泌体、类器官外泌体和血浆外泌体分离鉴定及全转录组测序分析
关联平台: Exoomics®, Research Reagents & Tools
关联服务与能力: Biofluid EV Isolation & Purification, Tissue EV Isolation & Purification, EV Basic Characterization (TEM/NTA/WB), EV Whole-Transcriptome Sequencing, Research Reagent / Product Supply
关联产品或试剂: Exosupur® EV Isolation/Purification Kit
参考文献
原始论文: Integrated transcriptomics, proteomics, and functional analysis to characterize the tissue-specific small extracellular vesicle network of breast cancer MedComm. 2023. DOI: 10.1002/mco2.433. PMID/PMCID: 38053815; PMC10694390.