肿瘤组织和血浆EVs的综合蛋白质组学分析确定了结直肠癌的诊断生物标志物panel

核心信息

• 论文英文标题: Integrative proteomic profiling of tumor and plasma extracellular vesicles identifies a diagnostic biomarker panel for colorectal cancer
• 期刊: Cell Rep Med
• 发表年份: 2025
• DOI: 10.1016/j.xcrm.2025.102090
• PMID/PMCID: 40311616; PMC12147850

研究概览

The lack of reliable non-invasive biomarkers for early colorectal cancer (CRC) diagnosis underscores the need for improved diagnostic tools. Our analysis of EV protein profiles from tissue and plasma demonstrates ColonTrack's potential as a robust non-invasive biomarker panel for CRC diagnosis and early detection.

核心发现

The lack of reliable non-invasive biomarkers for early colorectal cancer (CRC) diagnosis underscores the need for improved diagnostic tools.

Extracellular vesicles (EVs) have emerged as promising candidates for liquid-biopsy-based cancer monitoring.

Here, we propose a comprehensive workflow that integrates staged mass spectrometry (MS)-based discovery and verification with ELISA-based validation to identify EV protein biomarkers for CRC.

Our approach, applied to 1,272 individuals, yields a machine learning model, ColonTrack, incorporating EV proteins HNRNPK, CTTN, and PSMC6.

Echo Biotech 角色

Exosupur袖珍柱ES9016+外泌体粒径和电镜表征

关联平台: Exoomics®, Research Reagents & Tools

关联服务与能力: Tissue EV Isolation & Purification, EV Basic Characterization (TEM/NTA/WB), Research Reagent / Product Supply

关联产品或试剂: Exosupur® EV Isolation/Purification Kit

参考文献

原始论文: Integrative proteomic profiling of tumor and plasma extracellular vesicles identifies a diagnostic biomarker panel for colorectal cancer Cell reports Medicine. 2025. DOI: 10.1016/j.xcrm.2025.102090. PMID/PMCID: 40311616; PMC12147850.