鼓室内注射MSC sEV保护螺旋神经节神经元免于退化

核心信息

• 论文英文标题: Intratympanic injection of MSC-derived small extracellular vesicles protects spiral ganglion neurons from degeneration
• 期刊: Biomed Pharmacother
• 发表年份: 2024
• DOI: 10.1016/j.biopha.2024.117392
• PMID/PMCID: 39232388

研究概览

In this study, we investigated the efficacy of MSC-sEV for protection against ouabain-induced SGN degeneration. In conclusion, our findings demonstrate the potential of MSC-sEV in preventing SGN degeneration and promoting neural growth, suggesting intratympanic injection of MSC-sEV is a specific and efficient strategy for neural hearing loss.

核心发现

Sensorineural hearing loss is one of the most prevalent sensory deficits.

Spiral ganglion neurons (SGNs) exhibit very limited regeneration capacity and their degeneration leads to profound hearing loss.

Mesenchymal stem cell-derived small extracellular vesicles (MSC-sEV) have been demonstrated to repair tissue damage in various degenerative diseases.

However, the effects of MSC-sEV on SGN degeneration remain unclear.

Echo Biotech 角色

大鼠MSC细胞上清外泌体分离及电镜&粒径检测

关联平台: Exoomics®

关联服务与能力: Cell-Culture Supernatant EV Isolation & Purification, EV Basic Characterization (TEM/NTA/WB)

关联产品或试剂: 无明确产品引用

参考文献

原始论文: Intratympanic injection of MSC-derived small extracellular vesicles protects spiral ganglion neurons from degeneration Biomedicine & pharmacotherapy. 2024. DOI: 10.1016/j.biopha.2024.117392. PMID/PMCID: 39232388.