LncHLEF通过miR-2188-3pGATA6轴和编码肽促进肝脏脂质合成，并通过外泌体增强肌肉脂肪沉积

核心信息

• 论文英文标题: LncHLEF promotes hepatic lipid synthesis through miR-2188-3p/GATA6 axis and encoding peptides and enhances intramuscular fat deposition via exosome
• 期刊: Int J Biol Macromol
• 发表年份: 2023
• DOI: 10.1016/j.ijbiomac.2023.127061
• PMID/PMCID: 37751822

研究概览

In conclusion, this study revealed that the lncHLEF could promote hepatic lipid synthesis through two independent regulatory mechanisms, and could enhance IMF deposition via hepatocyte-adipocyte communications mediated by exosome. However, their biological functions and regulatory mechanisms underlying adipogenesis remain largely elusive in chicken.

核心发现

Long noncoding RNAs (lncRNAs) have emergingly been implicated in mammalian lipid metabolism.

However, their biological functions and regulatory mechanisms underlying adipogenesis remain largely elusive in chicken.

Here, we systematically characterized the genome-wide full-length lncRNAs in the livers of pre- and peak-laying hens, and identified a novel intergenic lncRNA, lncHLEF, an RNA macromolecule with a calculated molecular weight of 433 kDa.

lncHLEF was primarily distributed in cytoplasm of chicken hepatocyte and significantly up-regulated in livers of peak-laying hens.

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参考文献

原始论文: LncHLEF promotes hepatic lipid synthesis through miR-2188-3p/GATA6 axis and encoding peptides and enhances intramuscular fat deposition via exosome Int J Biol Macromol. 2023. DOI: 10.1016/j.ijbiomac.2023.127061. PMID/PMCID: 37751822.