心脏粘液瘤相关性缺血性卒中血浆和肿瘤组织外泌体lncRNA、miRNA和mRNA
核心信息
- 论文英文标题: lncRNA, miRNA, and mRNA of plasma and tumor-derived exosomes of cardiac myxoma-related ischaemic stroke
- 期刊: Sci Data
- 发表年份: 2025
- DOI: 10.1038/s41597-025-04410-4
- PMID/PMCID: 39820519; PMC11739660
研究概览
This dataset provides a significant resource for relevant researchers to explore the potential dysregulated lncRNAs, miRNAs, and mRNAs of plasma and tumour-derived exosomes in CM-IS. Tumour-derived exosomes play a crucial role in tumour growth, metastasis, immune regulation, and monitor disease development.
核心发现
Cardiac myxoma (CM) is an important aetiology of stroke in young adults, and its diagnosis is difficult in patients having stroke because of the lack of diagnostic biomarkers.
Tumour-derived exosomes play a crucial role in tumour growth, metastasis, immune regulation, and monitor disease development.
Hence,we established an RNA-sequencing dataset for long non-coding RNA (lncRNA), microRNA (miRNA), and messenger RNA (mRNA) in the plasma and tumour-derived exosomes from four patients with cardiac myxoma-related ischaemic stroke (CM-IS) and six patients with cardiac myxoma without ischaemic stroke (non-IS CM).
Moreover, 5,533 lncRNAs, 1,331 known miRNAs, and 412 new miRNAs were identified.
Echo Biotech 角色
血浆外泌体和组织外泌体分离鉴定&全转录组测序分析
关联平台: Exoomics®, Research Reagents & Tools
关联服务与能力: Biofluid EV Isolation & Purification, Tissue EV Isolation & Purification, EV Basic Characterization (TEM/NTA/WB), EV Whole-Transcriptome Sequencing, Research Reagent / Product Supply
关联产品或试剂: Exosupur® EV Isolation/Purification Kit
参考文献
原始论文: lncRNA, miRNA, and mRNA of plasma and tumor-derived exosomes of cardiac myxoma-related ischaemic stroke Scientific Data. 2025. DOI: 10.1038/s41597-025-04410-4. PMID/PMCID: 39820519; PMC11739660.