恶性腹水衍生的外泌体促进腹膜肿瘤细胞传播并揭示晚期胃癌中独特的miRNA特征

核心信息

• 论文英文标题: Malignant ascites-derived exosomes promote peritoneal tumor cell dissemination and reveal a distinct miRNA signature in advanced gastric cancer
• 期刊: Cancer Lett
• 发表年份: 2019
• DOI: 10.1016/j.canlet.2019.04.034
• PMID/PMCID: 31075288

研究概览

Thus, this study aims to investigate the effects of malignant ascites (MA)-derived exosomes from GC patients on tumor cells and to elucidate the underlying mechanism. However, the molecular mechanisms of PD remain poorly defined.

核心发现

Peritoneal dissemination (PD) is the most frequent metastasis with poor prognosis in patients with advanced gastric cancer (GC).

However, the molecular mechanisms of PD remain poorly defined.

Exosomes play a pivotal role in cancer progression.

Thus, this study aims to investigate the effects of malignant ascites (MA)-derived exosomes from GC patients on tumor cells and to elucidate the underlying mechanism.

Echo Biotech 角色

腹水外泌体分离鉴定&miRNA测序分析

关联平台: Exoomics®

关联服务与能力: Biofluid EV Isolation & Purification, EV Basic Characterization (TEM/NTA/WB), EV miRNA Profiling / Sequencing

关联产品或试剂: 无明确产品引用

参考文献

原始论文: Malignant ascites-derived exosomes promote peritoneal tumor cell dissemination and reveal a distinct miRNA signature in advanced gastric cancer Cancer Lett. 2019. DOI: 10.1016/j.canlet.2019.04.034. PMID/PMCID: 31075288.