间充质干细胞通过let‑7b‑5p改善顺铂诱导的急性肾损伤

核心信息

• 论文英文标题: Mesenchymal stem cells ameliorate cisplatin‑induced acute kidney injury via let‑7b‑5p
• 期刊: Cell Tissue Res
• 发表年份: 2022
• DOI: 10.1007/s00441-022-03729-3
• PMID/PMCID: 36543894; 3064140

研究概览

Acute kidney injury (AKI) is a clinically common kidney disease. Let-7b-5p downregulation may lead to increased renal AKI susceptibility, thus indicating that this miRNA is a potential driver of the MSC treatment response in AKI.

核心发现

Acute kidney injury (AKI) is a clinically common kidney disease.

Age is an important factor that contributes to the susceptibility to AKI.

Mesenchymal stem cells (MSCs) are a promising therapy for AKI, and miRNAs in exosomes (Exos) derived from MSCs are an important aspect of MSC treatment.

However, the therapeutic effect of miRNA from MSC-derived Exos on AKI and the related mechanism have not been fully clarified.

Echo Biotech 角色

MSC外泌体分离鉴定

关联平台: Exoomics®, Research Reagents & Tools

关联服务与能力: Cell-Culture Supernatant EV Isolation & Purification, EV Basic Characterization (TEM/NTA/WB), Research Reagent / Product Supply

关联产品或试剂: Exosupur® EV Isolation/Purification Kit

参考文献

原始论文: Mesenchymal stem cells ameliorate cisplatin‑induced acute kidney injury via let‑7b‑5p Cell Tissue Res. 2022. DOI: 10.1007/s00441-022-03729-3. PMID/PMCID: 36543894; 3064140.