MSC接受适应性胰岛衍生的含miR-151的sEV以促进肥胖状态下的β细胞补偿

核心信息

• 论文英文标题: Mesenchymal stem cells receive adaptive islet-derived miR-151-containing sEVs to promote β cell compensation in obesity
• 期刊: Sci Adv
• 发表年份: 2026
• DOI: 10.1126/sciadv.adu4196
• PMID/PMCID: 42467765; PMC13378542

研究概览

This study shows that adaptive islet-derived small extracellular vesicles (aid-sEVs) play a key role in β cell adaptation in obesity. These findings reveal a critical pathway controlling β cell compensation in diet-induced obesity and indicate that targeted enhancement of aid-sEV secretion could be a therapeutic strategy to counteract β cell dysfunction in diabetic patients.

核心发现

Pancreatic islets respond to obesity-related insulin resistance by increasing β cell mass and insulin secretion.

However, the molecular mechanisms behind this vital compensation are not fully understood.

This study shows that adaptive islet-derived small extracellular vesicles (aid-sEVs) play a key role in β cell adaptation in obesity.

Aid-sEV production rises under hyperlipidemic conditions, and uptake by adjacent cells occurs via F11R-mediated recognition.

Echo Biotech 角色

UC结合Exosupur排阻柱ES914分离胰岛组织/胰岛β细胞EV、ExoCCM无外泌体血清

关联平台: Exoomics®, Research Reagents & Tools

关联服务与能力: Biofluid EV Isolation & Purification, Tissue EV Isolation & Purification, Exosome-Depleted Serum / Medium Supply

关联产品或试剂: Exosupur® EV Isolation/Purification Kit, ExoCCM® Exosome-Depleted Serum/Medium

参考文献

原始论文: Mesenchymal stem cells receive adaptive islet-derived miR-151-containing sEVs to promote β cell compensation in obesity Science advances. 2026. DOI: 10.1126/sciadv.adu4196. PMID/PMCID: 42467765; PMC13378542.