血浆小细胞外囊泡miRNA作为抽动障碍诊断的潜在生物标记物

核心信息

• 论文英文标题: Micro-RNAs from Plasma-Derived Small Extracellular Vesicles as Potential Biomarkers for Tic Disorders Diagnosis
• 期刊: BRAIN SCI
• 发表年份: 2022
• DOI: 10.3390/brainsci12070829
• PMID/PMCID: 35884636; PMC9312839

研究概览

In our research, we finally obtained several potential sEVs-derived miRNA biomarkers to assess the diagnosis and prognosis of TDs. Micro-RNAs (miRNAs) derived from small extracellular vesicles (sEVs) have been recognized as novel circulating biomarkers of disease.

核心发现

, attention deficit hyperactivity disorder and obsessive-compulsive disorder), which indeed aggravate clinical symptoms and complicate diagnosis and treatment.

Micro-RNAs (miRNAs) derived from small extracellular vesicles (sEVs) have been recognized as novel circulating biomarkers of disease.

To identify specific miRNAs derived from plasma sEVs for TDs' diagnosis and prognosis, we used official EV isolation and purification methods to characterize the plasma-derived EV miRNAs from children with different types of TDs.

Nanoparticle tracking analysis, transmission electron microscopy, and immunoblot analysis of EV surface markers were applied to confirm the features and quality of sEVs.

Echo Biotech 角色

血浆外泌体miRNA测序未验证

关联平台: Exoomics®, Research Reagents & Tools

关联服务与能力: Biofluid EV Isolation & Purification, EV miRNA Profiling / Sequencing, Research Reagent / Product Supply

关联产品或试剂: Exosupur® EV Isolation/Purification Kit

参考文献

原始论文: Micro-RNAs from Plasma-Derived Small Extracellular Vesicles as Potential Biomarkers for Tic Disorders Diagnosis Brain Sciences. 2022. DOI: 10.3390/brainsci12070829. PMID/PMCID: 35884636; PMC9312839.