微滴增强芯片平台用于同时检测EVs RNA和膜蛋白筛选高通量免疫治疗标志物
核心信息
- 论文英文标题: Microdroplet-enhanced chip platform for high-throughput immunotherapy marker screening from extracellular vesicle RNAs and membrane proteins
- 期刊: Biosens Bioelectron
- 发表年份: 2024
- DOI: 10.1016/j.bios.2024.116748
- PMID/PMCID: 39276441
研究概览
In this work, we developed a high-throughput microdroplet-enhanced chip (MEC) platform, which utilizes thousands of individual microchambers (∼pL) as reactors, accelerating the detection efficiency of the CRISPR/Cas systems and increasing the sensitivity by up to 100-fold (aM level). Nevertheless, simultaneous detection of multiple EVs markers still presents significant technical challenges.
核心发现
Extracellular vesicles (EVs) are considered as promising candidates for predicting patients who respond to immunotherapy.
Nevertheless, simultaneous detection of multiple EVs markers still presents significant technical challenges.
In this work, we developed a high-throughput microdroplet-enhanced chip (MEC) platform, which utilizes thousands of individual microchambers (∼pL) as reactors, accelerating the detection efficiency of the CRISPR/Cas systems and increasing the sensitivity by up to 100-fold (aM level).
911) than the individual marker for the efficacy prediction of immunotherapy.
Echo Biotech 角色
赵立波博士是作者之一
关联平台: Corporate Research / Scientific Publications
关联服务与能力: Co-authored Scientific Research
关联产品或试剂: 无明确产品引用
参考文献
原始论文: Microdroplet-enhanced chip platform for high-throughput immunotherapy marker screening from extracellular vesicle RNAs and membrane proteins Biosensors & bioelectronics. 2024. DOI: 10.1016/j.bios.2024.116748. PMID/PMCID: 39276441.