miRNA-6084通过EVs协调结直肠癌的血管生成和肝转移

核心信息

• 论文英文标题: MicroRNA-6084 orchestrates angiogenesis and liver metastasis in colorectal cancer via extracellular vesicles
• 期刊: JCI Insight
• 发表年份: 2025
• DOI: 10.1172/jci.insight.189503
• PMID/PMCID: 40493409; PMC12288965

研究概览

Our study demonstrates that H-EVs induce angiogenesis and liver metastasis. In summary, our findings suggest that CRC-derived H-EVs promote angiogenesis and liver metastasis through the HIF1A/SP1/miR-6084/ANGPTL4 axis.

核心发现

The prognosis for colorectal cancer (CRC) patients with liver metastasis remains poor, and the molecular mechanisms driving CRC liver metastasis are not fully understood.

Tumor-derived hypoxia-induced extracellular vesicles have emerged as key players in inducing angiogenesis by transferring noncoding RNAs.

However, the specific role of CRC-derived hypoxic extracellular vesicles (H-EVs) in regulating premetastatic microenvironment (PMN) formation by inducing angiogenesis remains unclear.

Our study demonstrates that H-EVs induce angiogenesis and liver metastasis.

Echo Biotech 角色

细胞上清/血清外泌体分离和细胞上清外泌体miRNA芯片测序分析

关联平台: Exoomics®, Research Reagents & Tools

关联服务与能力: Biofluid EV Isolation & Purification, Cell-Culture Supernatant EV Isolation & Purification, EV miRNA Profiling / Sequencing, Research Reagent / Product Supply

关联产品或试剂: Exosupur® EV Isolation/Purification Kit

参考文献

原始论文: MicroRNA-6084 orchestrates angiogenesis and liver metastasis in colorectal cancer via extracellular vesicles JCI Insight. 2025. DOI: 10.1172/jci.insight.189503. PMID/PMCID: 40493409; PMC12288965.