帕金森病中脑组织细胞外囊泡的miRNAs表达谱分析
核心信息
- 论文英文标题: microRNAs profiling of small extracellular vesicles from midbrain tissue of Parkinson's disease
- 期刊: Front Mol Neurosci
- 发表年份: 2023
- DOI: 10.3389/fnmol.2023.1090556
- PMID/PMCID: 36818649; PMC9935574
研究概览
Small extracellular vesicles (sEVs) are generated by all types of cells during physiological or pathological conditions. In summary, miRNAs may play a significant role in the onset and development of PD, and miRNAs need to be selected carefully as a research subject for exploring the pathological mechanism and the potential therapeutic targets and diagnostic markers of PD.
核心发现
Small extracellular vesicles (sEVs) are generated by all types of cells during physiological or pathological conditions.
There is growing interest in tissue-derived small extracellular vesicles (tdsEVs) because they can be isolated from a single tissue source.
Knowing the representation profile of microRNA (miRNA) in midbrain tissue-derived sEVs (bdsEVs) and their roles is imperative for understanding the pathological mechanism and improving the diagnosis and treatment of Parkinson's disease (PD).
bdsEVs from a rat model of PD and a sham group were separated and purified using ultracentrifugation, size-exclusion chromatography (SEC), and ultrafiltration.
Echo Biotech 角色
大鼠中脑组织外泌体分离鉴定及miRNA测序分析
关联平台: Exoomics®, Research Reagents & Tools
关联服务与能力: Tissue EV Isolation & Purification, EV Basic Characterization (TEM/NTA/WB), EV miRNA Profiling / Sequencing, Research Reagent / Product Supply
关联产品或试剂: Exosupur® EV Isolation/Purification Kit
参考文献
原始论文: microRNAs profiling of small extracellular vesicles from midbrain tissue of Parkinson's disease Front Mol Neurosci. 2023. DOI: 10.3389/fnmol.2023.1090556. PMID/PMCID: 36818649; PMC9935574.