胆脂瘤组织外泌体miRNA分析揭示外泌体miR-223-3p和miR-142-5p是获得性中耳胆脂瘤的潜在生物标志物

核心信息

• 论文英文标题: miRNA Profiling of Cholesteatoma-Derived Exosomes Reveals Exosomal miR-223-3p and miR-142-5p as Potential Biomarkers for Acquired Middle Ear Cholesteatoma
• 期刊: World J Otorhinolaryngol Head Neck Surg
• 发表年份: 2025
• DOI: 10.1002/wjo2.70057

研究概览

We found 14 upregulated miRNAs and 25 downregulated miRNAs in the cholesteatoma‐derived exosomes. The potential roles of differentially expressed miRNAs (DE‐miRNAs) were investigated using Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses.

Echo Biotech 角色

组织外泌体分离表征&血浆外泌体qPCR分析

关联平台: Exoomics®, Research Reagents & Tools

关联服务与能力: Biofluid EV Isolation & Purification, Tissue EV Isolation & Purification, EV Basic Characterization (TEM/NTA/WB), qPCR Validation, Research Reagent / Product Supply

关联产品或试剂: Exosupur® EV Isolation/Purification Kit

参考文献

原始论文: miRNA Profiling of Cholesteatoma-Derived Exosomes Reveals Exosomal miR-223-3p and miR-142-5p as Potential Biomarkers for Acquired Middle Ear Cholesteatoma World Journal of Otorhinolaryngology-Head & Neck Surgery. 2025. DOI: 10.1002/wjo2.70057.