免疫刺激RNA RN7SL1的线粒体易位抑制先天免疫反应

核心信息

• 论文英文标题: Mitochondrial translocation of immunostimulatory RNA RN7SL1 suppresses innate immune responses
• 期刊: Acta Biochim Biophys Sin (Shanghai)
• 发表年份: 2026
• DOI: 10.3724/abbs.2026079
• PMID/PMCID: 42178286

研究概览

In this study, we demonstrate that the nuclear-encoded immunostimulatory RNA RN7SL1 could be translocated into the mitochondria from the cytosol. These findings reveal a novel mitochondrial function in suppressing the immune response induced by immunostimulatory RNA.

核心发现

The significance of mitochondria in innate immunity is increasingly recognized.

Mitochondrial immunostimulatory nucleic acids released into the cytosol can trigger an innate immune response.

However, the possibility of translocating immunostimulatory nucleic acids from the cytosol to the mitochondria remains unexplored.

In this study, we demonstrate that the nuclear-encoded immunostimulatory RNA RN7SL1 could be translocated into the mitochondria from the cytosol.

Echo Biotech 角色

去外膜线粒体RNA测序分析

关联平台: Exoomics®

关联服务与能力: Specialized RNA Sequencing

关联产品或试剂: 无明确产品引用

参考文献

原始论文: Mitochondrial translocation of immunostimulatory RNA RN7SL1 suppresses innate immune responses Acta biochimica et biophysica Sinica. 2026. DOI: 10.3724/abbs.2026079. PMID/PMCID: 42178286.