MRO-HNRNPU-CCL5反馈环放大M2巨噬细胞和乳腺癌细胞的串扰以驱动进展

核心信息

• 论文英文标题: MRO/HNRNPU/CCL5 feedback loop amplifies M2 macrophage and breast cancer cell crosstalk to drive progression
• 期刊: J Transl Med
• 发表年份: 2025
• DOI: 10.1186/s12967-025-06776-w
• PMID/PMCID: 40817243; PMC12355852

研究概览

M2 macrophages are known to enhance the malignant phenotype of breast cancer (BC) cells, yet the underlying mechanisms remain unclear. Targeting this feedback loop offers a potential therapeutic strategy for BC.

核心发现

Maestro (MRO) was involved in the crosstalk between M2 macrophages and BC cells.

MRO expression was elevated in BC tissues, particularly in those with high CD68 and CD206 expression, and correlated with poor prognosis.

MRO was highly expressed in M2 macrophages, and its mRNA was transferred from M2 macrophages to BC cells via exosomes.

Engineering exosomes with MRO knockdown demonstrated reduced tumor-promoting effects compared to controls.

研究设计

scRNA sequencing analysis, chromatin immunoprecipitation, immunoprecipitation, exosome isolation, and biological experiments were used to analyze this crosstalk.

Echo Biotech 角色

exoload试剂盒负载siRNA

关联平台: Echosome®, Research Reagents & Tools

关联服务与能力: Small RNA / Cargo Loading, Research Reagent / Product Supply

关联产品或试剂: ExoLoad® Nucleic Acid Loading Kit

参考文献

原始论文: MRO/HNRNPU/CCL5 feedback loop amplifies M2 macrophage and breast cancer cell crosstalk to drive progression Journal of translational medicine. 2025. DOI: 10.1186/s12967-025-06776-w. PMID/PMCID: 40817243; PMC12355852.