MSC外泌体miR-125b-5p抑制糖尿病视网膜病变中的视网膜微血管内皮细胞铁死亡

核心信息

• 论文英文标题: MSC-derived Exosomal miR-125b-5p Suppressed Retinal Microvascular Endothelial Cell Ferroptosis in Diabetic Retinopathy
• 期刊: Stem Cells
• 发表年份: 2025
• DOI: 10.1093/stmcls/sxaf023
• PMID/PMCID: 40247684

研究概览

In this study, MSC-sEVs mitigated retinal blood-retina barrier (BRB) impairment in rats with streptozotocin (STZ)-induced DR by reducing ferroptosis in vivo and in vitro. This study indicated the potential therapeutic effect of MSC-sEVs on vascular endothelial function maintenance and that the delivery of sEVs carrying miR-125b-5p could prevent endothelial cell ferroptosis by inhibiting P53, thereby protecting the BRB.

核心发现

Progressive endothelial cell injury of retinal vascular is a vital factor in diabetic retinopathy (DR) pathogenesis.

Mesenchymal stem cells-derived small extracellular vesicles (MSC-sEVs) showed beneficial effects on DR.

However, the effects of MSC-sEVs on endothelial dysfunction of DR and the mechanism is still unclear.

In this study, MSC-sEVs mitigated retinal blood-retina barrier (BRB) impairment in rats with streptozotocin (STZ)-induced DR by reducing ferroptosis in vivo and in vitro.

Echo Biotech 角色

细胞上清外泌体分离、miRNA测序分析

关联平台: Exoomics®

关联服务与能力: Cell-Culture Supernatant EV Isolation & Purification, EV miRNA Profiling / Sequencing

关联产品或试剂: 无明确产品引用

参考文献

原始论文: MSC-derived Exosomal miR-125b-5p Suppressed Retinal Microvascular Endothelial Cell Ferroptosis in Diabetic Retinopathy Stem cells. 2025. DOI: 10.1093/stmcls/sxaf023. PMID/PMCID: 40247684.