MSC衍生sEV通过miR-29a-3p调节小胶质细胞M1样极化减轻糖尿病视网膜病变

核心信息

• 论文英文标题: MSC-Derived Small Extracellular Vesicles attenuate diabetic retinopathy through miR-29a-3p regulated microglia M1-like polarization
• 期刊: Exp Eye Res
• 发表年份: 2025
• DOI: 10.1016/j.exer.2025.110586
• PMID/PMCID: 40840646

研究概览

In this study, intravitreal injection of sEVs reduced retinal inflammation, mitigated vascular leakage, and suppressed M1-like microglia via the HMGB1/TLR4 signaling pathway. MSC-sEVs and miRNAs may be explored as promising therapeutic targets for DR.

核心发现

Diabetic retinopathy (DR), considered as a neurovascular disorder, significantly causes permanent vision loss and blindness worldwide among working-age adults.

The inflammation caused by M1-like microglia is involved in DR.

Mesenchymal stem cell (MSC)-derived small extracellular vesicles (sEVs) is an attractive candidate for inflammation modulation.

However, the regulatory effect of sEVs secreted by MSCs on M1 differentiation of microglia in diabetic retinopathy has not been thoroughly investigated.

Echo Biotech 角色

外泌体miRNA芯片测序分析

关联平台: Exoomics®

关联服务与能力: EV miRNA Profiling / Sequencing

关联产品或试剂: 无明确产品引用

参考文献

原始论文: MSC-Derived Small Extracellular Vesicles attenuate diabetic retinopathy through miR-29a-3p regulated microglia M1-like polarization Experimental eye research. 2025. DOI: 10.1016/j.exer.2025.110586. PMID/PMCID: 40840646.