多组学研究揭示海洛因和甲基苯丙胺戒断期间神经递质、EVs miRNA和精神病合并症之间的关系

核心信息

  • 论文英文标题: Multi-omics study reveals associations among neurotransmitter, extracellular vesicle-derived microRNA and psychiatric comorbidities during heroin and methamphetamine withdrawal
  • 期刊: Biomed Pharmacother
  • 发表年份: 2022
  • DOI: 10.1016/j.biopha.2022.113685
  • PMID/PMCID: 36137407

研究概览

Despite decades of research in the field of substance withdrawal, molecular biomarkers and related mechanistic study have generally been lacking. Our results suggest that the miRNA content of circulating exosomes represent a biomolecular "fingerprint" of the progression of substance withdrawal and may uncover the putative mechanism of how these exosomal miRNAs contribute to psychiatric symptoms.

核心发现

Despite decades of research in the field of substance withdrawal, molecular biomarkers and related mechanistic study have generally been lacking.

In addition to known neurotransmitters, circulating miRNAs are found in small vesicles known as exosomes within blood that have diagnostic potential and are known to contribute to psychiatric disorders.

The aim of this work was to characterize the changes in neurotransmitter and exosomal miRNA profiles during heroin and methamphetamine withdrawal using a cross-sectional study design, and to determine their associations to psychiatric comorbidities in a large group of patients with substance use disorders (SUDs).

Using weighted gene co-expression network analysis, a series of known, conserved, and novel exosomal miRNAs were identified as being associated with the severity of anxiety and depression, as well as the concentrations of neurotransmitters GABA, choline, and serotonin.

Echo Biotech 角色

血浆外泌体分离及miRNA测序分析，与EA58同一项目，全转数据拆分发表

关联平台: Exoomics®, Research Reagents & Tools

关联服务与能力: Biofluid EV Isolation & Purification, EV miRNA Profiling / Sequencing, EV Whole-Transcriptome Sequencing, Research Reagent / Product Supply

关联产品或试剂: Exosupur® EV Isolation/Purification Kit

参考文献

原始论文: Multi-omics study reveals associations among neurotransmitter, extracellular vesicle-derived microRNA and psychiatric comorbidities during heroin and methamphetamine withdrawal Biomedecine & pharmacotherapie,. 2022. DOI: 10.1016/j.biopha.2022.113685. PMID/PMCID: 36137407.