THBS2+癌症相关成纤维细胞是促进早期肺腺癌侵袭性的关键因素-其中血浆外泌体ELISA、组织外泌体ELISA和酶消化试验验证蛋白外泌体膜定位，由恩泽康泰完成

核心信息

  • 论文英文标题: Multi-scale integrative analyses identify THBS2 + cancer-associated fibroblasts as a key orchestrator promoting aggressiveness in early-stage lung adenocarcinoma
  • 期刊: Theranostics
  • 发表年份: 2022
  • DOI: 10.7150/thno.69590
  • PMID/PMCID: 35547750; PMC9065207

研究概览

Results: We identified and validated THBS2, at multi-omic levels, as a tumor size-independent biomarker that robustly predicted post-surgical survival in multiple independent clinical cohorts of early-stage LUAD. However, biomarkers stratifying this high-risk subset and molecular underpinnings underlying the aggressive phenotype remain unclear.

核心发现

Rationale: Subsets of patients with early-stage lung adenocarcinoma (LUAD) have a poor post-surgical course after curative surgery.

However, biomarkers stratifying this high-risk subset and molecular underpinnings underlying the aggressive phenotype remain unclear.

Methods: We integrated bulk and single-cell transcriptomics, proteomics, secretome and spatial profiling of clinical early-stage LUAD samples to identify molecular underpinnings that promote the aggressive phenotype.

Results: We identified and validated THBS2, at multi-omic levels, as a tumor size-independent biomarker that robustly predicted post-surgical survival in multiple independent clinical cohorts of early-stage LUAD.

Echo Biotech 角色

Echo Biotech contributed EV isolation and purification; the study also used or cited Exosupur®.

关联平台: Exoomics®, Research Reagents & Tools

关联服务与能力: EV Isolation & Purification, Research Reagent / Product Supply

关联产品或试剂: Exosupur® EV Isolation/Purification Kit

参考文献

原始论文: Multi-scale integrative analyses identify THBS2 + cancer-associated fibroblasts as a key orchestrator promoting aggressiveness in early-stage lung adenocarcinoma Theranostics. 2022. DOI: 10.7150/thno.69590. PMID/PMCID: 35547750; PMC9065207.