慢性脑缺血时肌肉组织sEV介导运动诱导的认知保护

核心信息

• 论文英文标题: Muscle-Derived Small Extracellular Vesicles Mediate Exercise-Induced Cognitive Protection in Chronic Cerebral Hypoperfusion
• 期刊: Adv Sci (Weinh)
• 发表年份: 2025
• DOI: 10.1002/advs.202410209
• PMID/PMCID: 40271743; PMC12279231

研究概览

This study demonstrated that exercise promotes the secretion of muscle-derived small extracellular vesicles (sEVs), which facilitate interorgan communication between the muscle and the brain. Collectively, these findings identify miR-17/20a-5p in muscle-derived sEVs as the exercise-induced myokine with potent effects on the brain, emphasizing the therapeutic potential of exercise in managing cognitive impairment.

核心发现

Physical exercise protects against cognitive impairment caused by chronic cerebral hypoperfusion (CCH).

However, the mechanisms through which exercise sends signals from the periphery to the central nervous system remain incompletely understood.

This study demonstrated that exercise promotes the secretion of muscle-derived small extracellular vesicles (sEVs), which facilitate interorgan communication between the muscle and the brain.

Systematic delivery of muscle-derived sEVs enhances synaptic plasticity and alleviated cognitive impairment in CCH.

Echo Biotech 角色

组织/血浆外泌体分离、表征、工程化外泌体蛋白外载服务、电穿孔负载小核酸、ExoCoupl正交偶联试剂盒

关联平台: Exoomics®, Echosome®, Research Reagents & Tools

关联服务与能力: Biofluid EV Isolation & Purification, Tissue EV Isolation & Purification, EV Basic Characterization (TEM/NTA/WB), Engineered EV Development, Small RNA / Cargo Loading, Targeting Peptide / Surface Modification, EV Tracing & Uptake Analysis, Custom Ligand / Peptide-Lipid Synthesis, Research Reagent / Product Supply

关联产品或试剂: Exosupur® EV Isolation/Purification Kit, ExoCoupl® Bioorthogonal Coupling Kit

参考文献

原始论文: Muscle-Derived Small Extracellular Vesicles Mediate Exercise-Induced Cognitive Protection in Chronic Cerebral Hypoperfusion Advanced science. 2025. DOI: 10.1002/advs.202410209. PMID/PMCID: 40271743; PMC12279231.