多肽功能化牛奶EVs心肌递送miR30d靶向治疗肥厚性心力衰竭-IMTP脂锚+exoload

核心信息

• 论文英文标题: Myocardial delivery of miR30d with peptide-functionalized milk-derived extracellular vesicles for targeted treatment of hypertrophic heart failure
• 期刊: Biomaterials
• 发表年份: 2024
• DOI: 10.1016/j.biomaterials.2024.122976
• PMID/PMCID: 39637583

研究概览

Mechanistically, we identified GRK5 as an unprecedented target of miR30d in cardiac hypertrophy. However, effective delivery of miR30d to the heart is challenging.

核心发现

miR30d has been shown to reverse cardiac hypertrophy.

However, effective delivery of miR30d to the heart is challenging.

Here, we engineered milk-derived extracellular vesicles (mEVs) by surface functionalization with an ischemic myocardium-targeting peptide (IMTP) and encapsulated miR30d to develop a formulation, the miR30d-mEVsIMTP, enabling targeted delivery of miR30d to the injured heart.

In vitro, the miR30d-mEVsIMTP can be effectively internalized by hypoxia-induced H9C2 cells via the endo-lysosomal pathway.

Echo Biotech 角色

Echo Biotech contributed cargo loading; the study also used or cited ExoLoad®.

关联平台: Echosome®, Research Reagents & Tools

关联服务与能力: Small RNA / Cargo Loading, Research Reagent / Product Supply

关联产品或试剂: ExoLoad® Nucleic Acid Loading Kit

参考文献

原始论文: Myocardial delivery of miR30d with peptide-functionalized milk-derived extracellular vesicles for targeted treatment of hypertrophic heart failure Biomaterials. 2024. DOI: 10.1016/j.biomaterials.2024.122976. PMID/PMCID: 39637583.