m6A甲基化修饰通过富含circ-CDYL和EpCAM阳性的肝肿瘤起始外泌体促进肝癌发生

核心信息

• 论文英文标题: N6-methyladenosine modification promotes hepatocarcinogenesis through circ-CDYL-enriched and EpCAM-positive liver tumor-initiating exosomes
• 期刊: iScience
• 发表年份: 2023
• DOI: 10.1016/j.isci.2023.108022
• PMID/PMCID: 37954137; PMC10638478

研究概览

We found that Circ-CDYL is highly enriched in early HCC plasma exosomes. We found that Circ-CDYL is highly enriched in early HCC plasma exosomes.

核心发现

CircRNAs play multiple roles in a variety of cellular processes.

We found that Circ-CDYL is highly enriched in early HCC plasma exosomes.

Moreover, EpCAM+ HCC cells and exosomes had significant Circ-CDYL levels.

We postulated that Circ-CDYL-enriched and EpCAM-positive exosomes would function as liver tumor-initiating exosomes (LTi-Exos).

Echo Biotech 角色

外泌体电镜、粒径和WB鉴定

关联平台: Exoomics®

关联服务与能力: EV Basic Characterization (TEM/NTA/WB)

关联产品或试剂: 无明确产品引用

参考文献

原始论文: N6-methyladenosine modification promotes hepatocarcinogenesis through circ-CDYL-enriched and EpCAM-positive liver tumor-initiating exosomes iScience. 2023. DOI: 10.1016/j.isci.2023.108022. PMID/PMCID: 37954137; PMC10638478.