NIR-II工程化外泌体纳米治疗探针用于原位胶质母细胞瘤的“定向爆破”

核心信息

• 论文英文标题: NIR-II Engineered Exosome Nanotheranostic Probes for "Oriented Blasting" in Orthotopic Glioblastoma
• 期刊: ACS Nano
• 发表年份: 2025
• DOI: 10.1021/acsnano.5c01541
• PMID/PMCID: 40539986

研究概览

This study offers an effective approach to glioblastoma therapy by integrating precision-targeted delivery, multimodal imaging, and synergistic therapeutic effects. The findings provide a theranostics platform aimed at overcoming current treatment limitations and improving clinical outcomes for cancer.

核心发现

Glioblastoma (GBM), a highly aggressive and lethal brain tumor, presents a formidable clinical challenge due to its poor prognosis and lack of effective treatment options, underscoring the urgent need for innovative therapeutic strategies.

Here, we report a promising phototheranostic platform based on a near-infrared II (NIR-II) organic molecule, MYM, which combines robust fluorescence with potent photothermal and photodynamic therapeutic capabilities.

To maximize efficacy, MYM was encapsulated in exosomes derived from 293F cells and further functionalized with the iRGD peptide, enhancing both tumor targeting and penetration of the blood-brain barrier (MYM@iRGD-Exo).

In vivo, studies demonstrate that MYM@iRGD-Exo can effectively penetrate the blood-brain barrier and selectively target GBM cells.

Echo Biotech 角色

ContrExo外泌体参考品CTE-06和iRGD脂锚试剂盒

关联平台: Echosome®, EV Materials / Reference Materials, Research Reagents & Tools

关联服务与能力: Targeting Peptide / Surface Modification, EV Material / Reference Material Supply

关联产品或试剂: ExoBrooch™ Targeting Peptide/Lipid Anchor Kit, ContrExo® EV Reference Material

参考文献

原始论文: NIR-II Engineered Exosome Nanotheranostic Probes for "Oriented Blasting" in Orthotopic Glioblastoma ACS Nano. 2025. DOI: 10.1021/acsnano.5c01541. PMID/PMCID: 40539986.