NK细胞衍生EVs携带衰老细胞清除剂可消除化疗诱导的衰老性骨肉瘤细胞

核心信息

• 论文英文标题: NK-Cell-Derived Extracellular Vesicles Engineered to Carry Senolytics Eliminate Chemotherapy-Induced Senescent steosarcoma Cells
• 期刊: J Extracell Vesicles
• 发表年份: 2025
• DOI: 10.1002/jev2.70123
• PMID/PMCID: 40693561; PMC12281467

研究概览

In order to further improve the efficacy of chemotherapy on OS, here we developed a senolytic drug delivery system based on engineered Natural killer (NK) cell-derived extracellular vesicles (EVs) that can target OS cells. Treatment-induced senescence (TIS) can lead to incomplete tumour clearance and potential recurrence.

核心发现

Osteosarcoma (OS) is a type of bone tumour characterized by high risk of metastatic progression and recurrence after therapy.

Traditional tumour treatment methods such as radiotherapy and chemotherapy can lead to the accumulation of senescent cells in tumours.

Treatment-induced senescence (TIS) can lead to incomplete tumour clearance and potential recurrence.

Recently, the combination of chemotherapy drugs and senolytics drugs ('one-two punch' therapy) has become a promising strategy for improved tumour treatment, but this method also faces challenges in terms of safety and targeting specificity.

Echo Biotech 角色

iRGD脂锚靶向肽

关联平台: Echosome®, Research Reagents & Tools

关联服务与能力: Targeting Peptide / Surface Modification, Research Reagent / Product Supply

关联产品或试剂: ExoBrooch™ Targeting Peptide/Lipid Anchor Kit

参考文献

原始论文: NK-Cell-Derived Extracellular Vesicles Engineered to Carry Senolytics Eliminate Chemotherapy-Induced Senescent steosarcoma Cells Journal of Extracellular Vesicles. 2025. DOI: 10.1002/jev2.70123. PMID/PMCID: 40693561; PMC12281467.