含有miR-374a-5p的非小细胞肺癌NSCLC EVs通过影响血脑屏障通透性促进软脑膜转移

核心信息

• 论文英文标题: NSCLC extracellular vesicles containing miR-374a-5p promote leptomeningeal metastasis by influencing blood‒brain barrier permeability
• 期刊: Mol Cancer Res
• 发表年份: 2024
• DOI: 10.1158/1541-7786.MCR-24-0052
• PMID/PMCID: 38639925; PMC11294816

研究概览

The purpose of this study was to examine the clinical value and role of EV miRNAs in NSCLC-LM. Implications: These results suggest that serum NSCLC-derived EV miR-374a-5p is involved in premetastatic niche formation by regulating the permeability of the blood-brain barrier to promote NSCLC-LM and can be used as a blood biomarker for the diagnosis and prognosis of NSCLC-LM.

核心发现

Leptomeningeal metastasis (LM) is a devastating complication of advanced non-small cell lung cancer (NSCLC).

Its diagnosis and monitoring can be challenging.

Recently, extracellular vesicle (EV) miRNAs have become a new noninvasive diagnostic biomarker.

The purpose of this study was to examine the clinical value and role of EV miRNAs in NSCLC-LM.

Echo Biotech 角色

血浆外泌体分离鉴定及miRNA测序分析

关联平台: Exoomics®, Research Reagents & Tools

关联服务与能力: Biofluid EV Isolation & Purification, EV Basic Characterization (TEM/NTA/WB), EV miRNA Profiling / Sequencing, Research Reagent / Product Supply

关联产品或试剂: Exosupur® EV Isolation/Purification Kit

参考文献

原始论文: NSCLC extracellular vesicles containing miR-374a-5p promote leptomeningeal metastasis by influencing blood‒brain barrier permeability Mol Cancer Res. 2024. DOI: 10.1158/1541-7786.MCR-24-0052. PMID/PMCID: 38639925; PMC11294816.