一种具有器官顺应性、褶皱结构的生物电子贴片用于精确的细胞内递送

核心信息

• 论文英文标题: An organ-conformal, kirigami-structured bioelectronic patch for precise intracellular delivery
• 期刊: Cell
• 发表年份: 2026
• DOI: 10.1016/j.cell.2025.12.021
• PMID/PMCID: 41605209

研究概览

Efficient and precise delivery of therapeutics toward target loci of organs is crucial for effective disease therapy. However, conventional devices face remarkable challenges to achieve clinically desirable conformality, spatial controllability, and efficiency, especially to organs with complex anatomies, due to a lack of appropriate mechanical and/or material properties.

核心发现

Efficient and precise delivery of therapeutics toward target loci of organs is crucial for effective disease therapy.

However, conventional devices face remarkable challenges to achieve clinically desirable conformality, spatial controllability, and efficiency, especially to organs with complex anatomies, due to a lack of appropriate mechanical and/or material properties.

Here, we report a bioelectronic patch for organ-conformal, kirigami-structured electro-transfection (POCKET) that features high conformality enabled by parametric customization, achieving a theoretically maximum effective coverage area over the target organ.

The four-layered POCKET forms a unique nanopore-cell juxtaposition configuration at the tissue-device interface, which induces precise, uniform electro-perforation while expediting intracellular transport of payloads.

Echo Biotech 角色

UC+Exosupur分离组织外泌体(卵巢及输卵管)ES9P14e

关联平台: Exoomics®, Research Reagents & Tools

关联服务与能力: Tissue EV Isolation & Purification, Research Reagent / Product Supply

关联产品或试剂: Exosupur® EV Isolation/Purification Kit

参考文献

原始论文: An organ-conformal, kirigami-structured bioelectronic patch for precise intracellular delivery Cell. 2026. DOI: 10.1016/j.cell.2025.12.021. PMID/PMCID: 41605209.