周细胞通过调节肿瘤局部血管张力和血流动力学促进转移
核心信息
- 论文英文标题: Pericytes promote metastasis by regulating tumor local vascular tone and hemodynamics
- 期刊: Nat Commun
- 发表年份: 2025
- DOI: 10.1038/s41467-025-62475-6
- PMID/PMCID: 40753165; PMC12318036
研究概览
Hemodynamics are important for survival and extravasation of circulating tumor cells, whereas the effects of hemodynamics on tumor cell intravasation remain mostly unknown. These findings reveal that TPCs-regulated vasodilation and hemodynamics facilitate tumor metastasis, and provide a potential prognostic marker and therapeutic strategy for tumor metastasis.
核心发现
Hemodynamics are important for survival and extravasation of circulating tumor cells, whereas the effects of hemodynamics on tumor cell intravasation remain mostly unknown.
Here, we show that colorectal cancer patients with liver metastasis are characterized by increased diameter and blood flow in the primary tumor compared with non-metastatic patients.
A subpopulation of NKX2-3high tumor pericytes (TPCs) in the primary tumor is associated with hematogenous metastasis of patients.
Mechanistically, long noncoding RNA NEAT1-enriched extracellular vesicles induce NKX2-3 upregulation in TPCs.
Echo Biotech 角色
Exosupur®血浆排阻柱ES9P11e
关联平台: Exoomics®, Research Reagents & Tools
关联服务与能力: Biofluid EV Isolation & Purification, Research Reagent / Product Supply
关联产品或试剂: Exosupur® EV Isolation/Purification Kit
参考文献
原始论文: Pericytes promote metastasis by regulating tumor local vascular tone and hemodynamics Nature communications. 2025. DOI: 10.1038/s41467-025-62475-6. PMID/PMCID: 40753165; PMC12318036.