胎盘滋养层细胞来源的外泌体 microRNA-1290 通过靶向 LHX6 促进子宫内膜与胚胎之间互作

核心信息

• 论文英文标题: Placental trophoblast cells-derived exosomal microRNA-1290 promotes the interaction between endometrium and embryo by targeting LHX6
• 期刊: Mol Ther Nucl Acids
• 发表年份: 2021
• DOI: 10.1016/j.omtn.2021.09.009
• PMID/PMCID: 34729246; PMC8526418

研究概览

Subsequently, we evaluated the loading miRNA in exosomes by small RNA sequencing. Altogether, our findings provide novel insights into the mechanism of trophoblast cell-derived exosomes during embryo implantation.

核心发现

Communication between the maternal uterus and the embryo is vital for a successful pregnancy.

Exosomes, subtypes of extracellular vesicles comprising many bioactive factors, regulate the early stages of pregnancy, specifically during embryo implantation.

Nevertheless, the mechanism by which exosomal microRNAs (miRNAs) derived from placental trophoblasts regulate embryo implantation remains elusive.

We isolated and identified exosomes derived from placental trophoblast cells (HTR8/SVneo).

Echo Biotech 角色

外泌体miRNA测序分析

关联平台: Exoomics®

关联服务与能力: EV miRNA Profiling / Sequencing

关联产品或试剂: 无明确产品引用

参考文献

原始论文: Placental trophoblast cells-derived exosomal microRNA-1290 promotes the interaction between endometrium and embryo by targeting LHX6 Mol Ther Nucl Acids. 2021. DOI: 10.1016/j.omtn.2021.09.009. PMID/PMCID: 34729246; PMC8526418.