血浆外泌体miRNA图谱揭示卵巢早衰的潜在表观遗传学发病机制

核心信息

• 论文英文标题: Plasma-derived exosomal miRNA profiles reveal potential epigenetic pathogenesis of premature ovarian failure
• 期刊: Hum Genet
• 发表年份: 2023
• DOI: 10.1007/s00439-023-02618-1
• PMID/PMCID: 38054996; 7487655

研究概览

This study aimed to investigate the epigenetic pathogenesis of POF through exosomal miRNA sequencing. Particularly, hsa-miR-19b-3p emerged as a potential regulator of BMPR2 and demonstrated its functional significance in POF through modulation of apoptosis.

核心发现

The role of plasma-derived exosomal miRNA in premature ovarian failure (POF) remains unclear.

This study aimed to investigate the epigenetic pathogenesis of POF through exosomal miRNA sequencing.

Exosomes were isolated and characterized from six POF patients and four healthy individuals using nanoparticle tracking analysis, transmission electron microscopy and western blot analysis.

Bioinformatics analysis in GSE39501 dataset and our sequencing data was conducted to investigate underlying mechanisms of POF.

Echo Biotech 角色

血浆外泌体分离鉴定及miRNA测序分析

关联平台: Exoomics®

关联服务与能力: Biofluid EV Isolation & Purification, EV Basic Characterization (TEM/NTA/WB), EV miRNA Profiling / Sequencing

关联产品或试剂: 无明确产品引用

参考文献

原始论文: Plasma-derived exosomal miRNA profiles reveal potential epigenetic pathogenesis of premature ovarian failure Hum Genet. 2023. DOI: 10.1007/s00439-023-02618-1. PMID/PMCID: 38054996; 7487655.