脓毒症诱导的急性肺损伤患者血浆EVs为肺泡巨噬细胞的自噬和铁死亡提供了条件

核心信息

• 论文英文标题: Plasma-derived extracellular vesicles prime alveolar macrophages for autophagy and ferroptosis in sepsis-induced acute lung injury
• 期刊: Mol Med
• 发表年份: 2025
• DOI: 10.1186/s10020-025-01111-x
• PMID/PMCID: 39901167; PMC11792199

研究概览

In this study, an investigation was conducted to map the miRNA and protein expression profiles of EVs derived from septic plasma. These findings suggest a novel mechanism of plasma-AM interaction in sepsis-induced ALI, offering a plausible strategy for assessing septic progression and treating lung injury.

核心发现

Sepsis-induced acute respiratory distress syndrome (ARDS) is a severe complication of sepsis and the leading cause of mortality.

Although the role of alveolar macrophages (AMs) in stabilizing pulmonary homeostasis is well established, the effects of circulating extracellular vesicles (EVs) on AMs remain largely unknown.

In this study, an investigation was conducted to map the miRNA and protein expression profiles of EVs derived from septic plasma.

Notably, EV-based panels (miR-122-5p, miR-125b-5p, miR-223-3p, OLFM4, and LCN2) have been found to be associated with the severity or prognosis of sepsis, with promising AUC values.

Echo Biotech 角色

血浆外泌体分离试剂盒Exosupur ES9P14e

关联平台: Exoomics®, Research Reagents & Tools

关联服务与能力: Biofluid EV Isolation & Purification, Research Reagent / Product Supply

关联产品或试剂: Exosupur® EV Isolation/Purification Kit

参考文献

原始论文: Plasma-derived extracellular vesicles prime alveolar macrophages for autophagy and ferroptosis in sepsis-induced acute lung injury Molecular medicine. 2025. DOI: 10.1186/s10020-025-01111-x. PMID/PMCID: 39901167; PMC11792199.