血浆外泌体hsa_circ_0079439作为胃癌早期检测的新标志物

核心信息

• 论文英文标题: Plasma exosomal hsa_circ_0079439 as a novel biomarker for early detection of gastric cancer
• 期刊: WORLD J GASTROENTERO
• 发表年份: 2023
• DOI: 10.3748/wjg.v29.i22.3482
• PMID/PMCID: 37389236; PMC10303519

研究概览

There were 303 participants, including 240 GC patients and 63 HDs, involved in the study. Therefore, plasma exosomal hsa_circ_0079439 might be a potential biomarker for the diagnosis of GC during both the early and late stages.

核心发现

There were 303 participants, including 240 GC patients and 63 HDs, involved in the study.

However, the levels of standard serum biomarkers were similar between the two groups.

研究设计

Healthy donors (HDs) and GC patients diagnosed by pathology were recruited.

Nine GC patients and three HDs were selected for exosomal whole-transcriptome RNA sequencing.

The expression profiles of circRNAs were analyzed by bioinformatics methods and validated by droplet digital polymerase chain reaction.

Echo Biotech 角色

外泌体分离鉴定及长链RNA测序分析

关联平台: Exoomics®, Research Reagents & Tools

关联服务与能力: EV Isolation & Purification, EV Basic Characterization (TEM/NTA/WB), EV lncRNA/mRNA Sequencing, Research Reagent / Product Supply

关联产品或试剂: Exosupur® EV Isolation/Purification Kit

参考文献

原始论文: Plasma exosomal hsa_circ_0079439 as a novel biomarker for early detection of gastric cancer World journal of gastroenterology. 2023. DOI: 10.3748/wjg.v29.i22.3482. PMID/PMCID: 37389236; PMC10303519.