原发性干燥综合征患者血浆EVs促进卵泡T辅助细胞扩增

核心信息

• 论文英文标题: Plasma extracellular vesicles promote follicular T helper cell expansion in primary Sjögren's syndrome
• 期刊: Clin Immunol
• 发表年份: 2025
• DOI: 10.1016/j.clim.2025.110458
• PMID/PMCID: 39978662

研究概览

Primary Sjögren's syndrome (pSS) is a prevalent autoimmune disease characterized by exocrine gland dysfunction, with hallmarks of B cell and T cell overactivation, whose underlying mechanism remains largely unknown. These findings suggested pSS plasma EVs as an important contributor to pSS pathogenesis, which was of potential clinical interest in managing pSS.

核心发现

Primary Sjögren's syndrome (pSS) is a prevalent autoimmune disease characterized by exocrine gland dysfunction, with hallmarks of B cell and T cell overactivation, whose underlying mechanism remains largely unknown.

Herein, we show that pSS plasma contained more extracellular vesicles (EVs) than HC plasma, which promoted CD4+ T cell activation, Th1, and follicular T helper cell (Tfh) differentiation, aggravating pSS immunopathology.

Notably, pSS plasma EVs were enriched with miR-501-3p, mediating CD4+ T cell activation and Tfh cell differentiation.

Furthermore, miR-501-3p downregulated special AT-rich sequence-binding protein-1 (SATB1) to promote Tfh differentiation.

Echo Biotech 角色

血浆外泌体分离表征&miRNA测序分析

关联平台: Exoomics®, Research Reagents & Tools

关联服务与能力: Biofluid EV Isolation & Purification, EV Basic Characterization (TEM/NTA/WB), EV miRNA Profiling / Sequencing, Research Reagent / Product Supply

关联产品或试剂: Exosupur® EV Isolation/Purification Kit

参考文献

原始论文: Plasma extracellular vesicles promote follicular T helper cell expansion in primary Sjögren's syndrome Clinical immunology. 2025. DOI: 10.1016/j.clim.2025.110458. PMID/PMCID: 39978662.