血小板生物工程化的人诱导多能干细胞EV在临床前窦房结功能障碍模型中实现对纤维化窦房结的靶向修复

核心信息

• 论文英文标题: Platelet-bioengineered hiPSC-sEVs achieve targeted repair of fibrotic sinoatrial node in preclinical SND models
• 期刊: Nat Commun
• 发表年份: 2025
• DOI: 10.1038/s41467-025-65936-0
• PMID/PMCID: 41365863; PMC12689679

研究概览

This study establishes a targeted, cell-free nanotherapeutic platform for resolving fibrosis and electrophysiological dysfunction in sinus node disease. Small extracellular vesicles derived from human induced pluripotent stem cells possess regenerative potential but lack targeted delivery.

核心发现

Sinus node dysfunction, a prevalent arrhythmia in aging populations, is characterized by fibrosis and loss of pacemaker activity, necessitating pacemaker implantation.

Current therapies fail to reverse the underlying pathology.

Small extracellular vesicles derived from human induced pluripotent stem cells possess regenerative potential but lack targeted delivery.

Here, we engineer platelet membrane-fused vesicles that synergistically combine collagen targeting for ischemic injury homing with immune evasion.

Echo Biotech 角色

The Exosupur® kit (ES8500/910, Echo Biotech)

关联平台: Exoomics®, Research Reagents & Tools

关联服务与能力: Cell-Culture Supernatant EV Isolation & Purification, Research Reagent / Product Supply

关联产品或试剂: Exosupur® EV Isolation/Purification Kit

参考文献

原始论文: Platelet-bioengineered hiPSC-sEVs achieve targeted repair of fibrotic sinoatrial node in preclinical SND models Nature communications. 2025. DOI: 10.1038/s41467-025-65936-0. PMID/PMCID: 41365863; PMC12689679.