血小板衍生外泌体通过调节miR-34a-5p表达调节冠状动脉血栓形成中内皮细胞炎症和M1巨噬细胞极化
核心信息
- 论文英文标题: Platelet-derived exosomes regulate endothelial cell inflammation and M1 macrophage polarization in coronary artery thrombosis via modulating miR-34a-5p expression
- 期刊: Sci Rep
- 发表年份: 2024
- DOI: 10.1038/s41598-024-67654-x
- PMID/PMCID: 39075107; PMC11286768
研究概览
Based on these facts, this study was conducted to investigate the acting mechanism of platelet-derived exosomes (PLT-exo) in the effects of endothelial injury and M1 macrophage polarization on coronary artery thrombosis. In contrast, miR-34a-5p overexpression in PLT-exo may exacerbate these pathological injuries in coronary artery thrombosis.
核心发现
As the important factors in coronary artery thrombosis, endothelial injury and M1 macrophage polarization are closely related to the expression of miR-34a-5p.
Exosomes in plasma are mainly derived from platelets and play an important role in thrombosis.
Based on these facts, this study was conducted to investigate the acting mechanism of platelet-derived exosomes (PLT-exo) in the effects of endothelial injury and M1 macrophage polarization on coronary artery thrombosis.
Firstly, rats were divided into the sham-operated group and the coronary microembolization (CME) group, and their plasma-derived exosomes were extracted to detect the expression of miR-34a-5p.
Echo Biotech 角色
富血小板血浆PRP外泌体分离鉴定及qPCR检测分析
关联平台: Exoomics®
关联服务与能力: Biofluid EV Isolation & Purification, EV Basic Characterization (TEM/NTA/WB), qPCR Validation
关联产品或试剂: 无明确产品引用
参考文献
原始论文: Platelet-derived exosomes regulate endothelial cell inflammation and M1 macrophage polarization in coronary artery thrombosis via modulating miR-34a-5p expression Scientific reports. 2024. DOI: 10.1038/s41598-024-67654-x. PMID/PMCID: 39075107; PMC11286768.