PlexinA（PLXNA）作为一种新型的细胞外囊泡工程化支架蛋白

核心信息

  • 论文英文标题: PlexinA (PLXNA) as a novel scaffold protein for the engineering of extracellular vesicles
  • 期刊: J Extracell Vesicles
  • 发表年份: 2024
  • DOI: 10.1002/jev2.70012
  • PMID/PMCID: 39508411; PMC11541859

研究概览

Extracellular vesicles (EVs) had been described as a next-generation drug delivery system, due to the compelling evidence that they can facilitate the transfer of a variety of biomolecules between cells. The identified scaffold protein PLXNA1 showed great potential in developing therapeutic EVs.

核心发现

Extracellular vesicles (EVs) had been described as a next-generation drug delivery system, due to the compelling evidence that they can facilitate the transfer of a variety of biomolecules between cells.

The most frequently used strategy for loading protein cargoes is the endogenous engineering of EVs through genetic fusion of the protein of interest (POI) and scaffold proteins with high EV-sorting ability.

However, the lack of scaffold proteins had become a major issue hindering the promotion of this technology.

Herein, we proposed novel screening criteria that relax the inclusion requirement of candidate scaffold proteins and eventually identified a new scaffold protein, PLXNA1.

Echo Biotech 角色

赵立波博士通讯，公司自主发文，工程化蛋白负载支架蛋白

关联平台: Exoomics®, Echosome®, Research Reagents & Tools

关联服务与能力: EV Isolation & Purification, Small RNA / Cargo Loading, Co-authored Scientific Research, Research Reagent / Product Supply

关联产品或试剂: Exosupur® EV Isolation/Purification Kit

参考文献

原始论文: PlexinA (PLXNA) as a novel scaffold protein for the engineering of extracellular vesicles Journal of Extracellular Vesicles. 2024. DOI: 10.1002/jev2.70012. PMID/PMCID: 39508411; PMC11541859.