M2型单核细胞衍生的外泌体介导的氨基富勒烯的潜在耐药性

核心信息

• 论文英文标题: Potential Resistance to Antineoplastic Aminated Fullerenes Mediated by M2-Like Monocyte-Derived Exosomes
• 期刊: FRONT ONCOL
• 发表年份: 2022
• DOI: 10.3389/fonc.2022.779939
• PMID/PMCID: 35433481; PMC9009388

研究概览

Exosomes are small extracellular vesicles critical for intercellular signaling via their delivery of cargoes, including proteins, DNA, RNA, lipids, and metabolites. Notably, C70-EDA-induced M2-like monocytes released exosomes that triggered the proliferation of recipient tumor cells, which may alleviate the antineoplastic efficacy of C70-EDA.

核心发现

Exosomes are small extracellular vesicles critical for intercellular signaling via their delivery of cargoes, including proteins, DNA, RNA, lipids, and metabolites.

Exosomes play essential roles in remodeling the tumor microenvironment (TME) for tumor growth, metastasis, and drug resistance.

, C70-ethylenediamine [EDA]) exhibit antineoplastic effects by targeting multiple functional proteins.

Nanosized C70-EDA with positive surface charges tends to be taken up by monocytes in the bloodstream and monocyte-derived macrophages in the TME.

Echo Biotech 角色

外泌体蛋白质组

关联平台: Exoomics®

关联服务与能力: EV Proteomics

关联产品或试剂: 无明确产品引用

参考文献

原始论文: Potential Resistance to Antineoplastic Aminated Fullerenes Mediated by M2-Like Monocyte-Derived Exosomes FRONT ONCOL. 2022. DOI: 10.3389/fonc.2022.779939. PMID/PMCID: 35433481; PMC9009388.