外泌体miRNA和膜蛋白在急性HIV感染者中的潜在作用
核心信息
- 论文英文标题: The potential role of exosomal miRNAs and membrane proteins in acute HIV-infected people
- 期刊: Front Immunol
- 发表年份: 2022
- DOI: 10.3389/fimmu.2022.939504
- PMID/PMCID: 36032099; PMC9411714
研究概览
In this study, exosomal miRNAs sequencing and mass cytometry were used to identify differential exosomal miRNAs and membrane proteins that participate in the pathogenesis of TPs and RPs. Yet, information regarding its cargo and its association with HIV rapid progressors (RPs) and typical progressors (TPs) remain largely unknown.
核心发现
Exosomes play an important role during human immunodeficiency virus (HIV) acute infection.
Yet, information regarding its cargo and its association with HIV rapid progressors (RPs) and typical progressors (TPs) remain largely unknown.
In this study, exosomal miRNAs sequencing and mass cytometry were used to identify differential exosomal miRNAs and membrane proteins that participate in the pathogenesis of TPs and RPs.
We discovered that miR-144-5p, miR-1180-3p, miR-451a, miR-362-5p, and miR-625-5p are associated with the TPs and miR-362-5p with the RPs.
Echo Biotech 角色
血浆外泌体分离及miRNA测序分析
关联平台: Exoomics®, Research Reagents & Tools
关联服务与能力: Biofluid EV Isolation & Purification, EV miRNA Profiling / Sequencing, Research Reagent / Product Supply
关联产品或试剂: Exosupur® EV Isolation/Purification Kit
参考文献
原始论文: The potential role of exosomal miRNAs and membrane proteins in acute HIV-infected people Front Immunol. 2022. DOI: 10.3389/fimmu.2022.939504. PMID/PMCID: 36032099; PMC9411714.