首个精神分裂症患者单外泌体表面蛋白表达特征的初步研究

核心信息

• 论文英文标题: Profiling expressing features of surface proteins on single-exosome in first-episode Schizophrenia patients: a preliminary study
• 期刊: Schizophrenia
• 发表年份: 2024
• DOI: 10.1038/s41537-024-00510-z
• PMID/PMCID: 39349515; PMC11443124

研究概览

Proximity barcoding assay, a high-throughput method for single-exosome analysis, was employed to profile surface proteins on individual exosomes of SCZ patients. This analysis identified five differentially expressed proteins (DEPs) between SCZ patients and healthy controls (HC) and six DEPs between antipsychotic responders and non-responders.

核心发现

Proximity barcoding assay, a high-throughput method for single-exosome analysis, was employed to profile surface proteins on individual exosomes of SCZ patients.

This analysis identified five differentially expressed proteins (DEPs) between SCZ patients and healthy controls (HC) and six DEPs between antipsychotic responders and non-responders.

Furthermore, two exosome clusters were found to be associated with SCZ, and certain DEPs were correlated with cognitive functions.

Echo Biotech 角色

血浆外泌体分离表征&PBA单囊泡膜蛋白质组学

关联平台: Exoomics®

关联服务与能力: Biofluid EV Isolation & Purification, EV Basic Characterization (TEM/NTA/WB), EV Proteomics

关联产品或试剂: 无明确产品引用

参考文献

原始论文: Profiling expressing features of surface proteins on single-exosome in first-episode Schizophrenia patients: a preliminary study Schizophrenia. 2024. DOI: 10.1038/s41537-024-00510-z. PMID/PMCID: 39349515; PMC11443124.