伴有焦虑和抑郁的物质使用障碍患者的预后血浆外泌体 microRNA 生物标志物

核心信息

  • 论文英文标题: Prognostic plasma exosomal microRNA biomarkers in patients with substance use disorders presenting comorbid with anxiety and depression
  • 期刊: SCI REP-UK
  • 发表年份: 2021
  • DOI: 10.1038/s41598-021-84501-5
  • PMID/PMCID: 33737514; PMC7973758

研究概览

Our study suggests that a set of circulating exosomal miRNAs were associated with anxiety and depression in SUD patients and may have clinical utility as diagnostic and prognostic biomarkers. Exosomes play significant roles in biological functions and regulate numerous physiological and pathological processes in various diseases, in particular substance use disorders (SUDs) and other psychiatric disorders.

核心发现

Psychiatric disorders such as anxiety and depression precipitated by substance use occurred during both use and withdrawal.

Exosomes play significant roles in biological functions and regulate numerous physiological and pathological processes in various diseases, in particular substance use disorders (SUDs) and other psychiatric disorders.

To better understand the role of exosomal miRNAs in the pathology of symptoms of anxiety and depression in patients with SUDs, we first isolated circulating exosomes from heroin-dependent patients (HDPs) and methamphetamine-dependent patients (MDPs) and identified exosomal miRNAs that were differentially expressed between patients and healthy controls (HCs).

Furthermore, the correlations between exosomal DE-miRNAs and symptoms of anxiety and depression which were measured using Hamilton-Anxiety (HAM-A)/Hamilton-Depression (HAM-D) Rating Scales in the participants.

Echo Biotech 角色

血浆外泌体miRNA测序分析

关联平台: Exoomics®, Research Reagents & Tools

关联服务与能力: Biofluid EV Isolation & Purification, EV miRNA Profiling / Sequencing, Research Reagent / Product Supply

关联产品或试剂: Exosupur® EV Isolation/Purification Kit

参考文献

原始论文: Prognostic plasma exosomal microRNA biomarkers in patients with substance use disorders presenting comorbid with anxiety and depression SCI REP-UK. 2021. DOI: 10.1038/s41598-021-84501-5. PMID/PMCID: 33737514; PMC7973758.