前列腺癌组织EV蛋白组学揭示代谢变化
核心信息
- 论文英文标题: Proteomics of Prostate Cancer Tissue Small Extracellular Vesicles Reveal Alteration of Metabolism
- 期刊: Proteomics
- 发表年份: 2025
- DOI: 10.1002/pmic.70081
- PMID/PMCID: 41243699; PMC12976852
研究概览
Leveraging our expertise in murine PCa model establishment and EV isolation from prostate tissue, this study aimed to characterize functional differences between PCa and normal prostate tissue via proteomic analysis of tissue-derived sEVs. These differential proteins in PCa tissue EVs reflect metabolic changes in PCa and may provide insights into the development of early diagnostic biomarkers or novel therapeutic strategies.
核心发现
Prostate cancer (PCa) is a leading male malignancy worldwide, with metabolic reprogramming being a critical hallmark of its progression.
Extracellular vesicles (EVs) derived from tissues directly reflect the tumor microenvironment, offering unique insights into cancer pathophysiology that are unattainable through cell line or biofluid-derived EVs.
However, the functional roles of tissue-derived EVs in PCa metabolism remain poorly understood.
Leveraging our expertise in murine PCa model establishment and EV isolation from prostate tissue, this study aimed to characterize functional differences between PCa and normal prostate tissue via proteomic analysis of tissue-derived sEVs.
Echo Biotech 角色
小鼠模型前列腺癌组织外泌体NTA鉴定&LFQ蛋白质组学
关联平台: Exoomics®
关联服务与能力: EV Basic Characterization (TEM/NTA/WB), EV Proteomics
关联产品或试剂: 无明确产品引用
参考文献
原始论文: Proteomics of Prostate Cancer Tissue Small Extracellular Vesicles Reveal Alteration of Metabolism Proteomics. 2025. DOI: 10.1002/pmic.70081. PMID/PMCID: 41243699; PMC12976852.