恢复心磷脂稳态可通过抑制ATG5介导的神经元自噬依赖性铁死亡来减轻脑缺血再灌注损伤

核心信息

• 论文英文标题: Restoring cardiolipin homeostasis mitigates cerebral ischemia-reperfusion injury by suppressing ATG5-mediated neuronal autophagy-dependent ferroptosis
• 期刊: J Adv Res
• 发表年份: 2026
• DOI: 10.1016/j.jare.2026.03.014
• PMID/PMCID: 41831680

研究概览

This study aimed to characterize CL alterations following cerebral I/R injury, identify potential mechanisms underlying CL loss, and investigate the pathophysiological effects of these changes. However, their roles in cerebral ischemia/reperfusion (I/R) injury remains largely underexplored.

核心发现

Significant CL depletion and acyl chain remodeling were observed in peri-infarct brain tissues.

EV-mediated release was identified as one of the mechanisms of CL loss, and inhibiting EV release restored neuronal CL levels.

SS-31 inhibits CL release, preserves CL content, and subsequently restores CL homeostasis.

Restoring CL homeostasis attenuated cerebral I/R injury by suppressing neuronal ferroptosis.

研究设计

Ischemic stroke was modeled by using middle cerebral occlusion/reperfusion (MCAO/R) in mice and oxygen-glucose deprivation/reoxygenation (OGD/R) in vitro.

CL alterations following cerebral I/R injury were evaluated through lipidomic analysis and fluorescent staining.

The role of extracellular vesicles (EVs) in CL release was investigated.

Echo Biotech 角色

微量血浆排阻柱ES9P024e

关联平台: Exoomics®, Research Reagents & Tools

关联服务与能力: Biofluid EV Isolation & Purification, Research Reagent / Product Supply

关联产品或试剂: Exosupur® EV Isolation/Purification Kit

参考文献

原始论文: Restoring cardiolipin homeostasis mitigates cerebral ischemia-reperfusion injury by suppressing ATG5-mediated neuronal autophagy-dependent ferroptosis Journal of advanced research. 2026. DOI: 10.1016/j.jare.2026.03.014. PMID/PMCID: 41831680.