益生菌大肠杆菌Nissle 1917衍生的各种大小的外膜囊泡OMVs的分离和异质性表征

核心信息

• 论文英文标题: Separation and Characterization of Heterogeneity Among Various Sizes of Outer Membrane Vesicles Derived from the Probiotic Escherichia coli Nissle 1917
• 期刊: Membranes (Basel)
• 发表年份: 2025
• DOI: 10.3390/membranes15050141
• PMID/PMCID: 40422751; PMC12113494

研究概览

To address this knowledge gap, we developed a membrane filtration method to isolate EcN-derived OMVs of varying sizes. OMVs contain various biologically active substances from their parent bacteria, such as proteins, lipids, and nucleic acids.

核心发现

Outer membrane vesicles (OMVs) are extracellular vesicles secreted by Gram-negative bacteria with diameters of 20-250 nm.

OMVs contain various biologically active substances from their parent bacteria, such as proteins, lipids, and nucleic acids.

Escherichia coli Nissle 1917 (EcN) is a Gram-negative probiotic that resides in the human intestine.

EcN-derived OMVs are pivotal in modulating intestinal immune responses.

Echo Biotech 角色

Exosupur排阻柱ES914纯化细菌OMV

关联平台: Exoomics®, Research Reagents & Tools

关联服务与能力: EV Isolation & Purification, Research Reagent / Product Supply

关联产品或试剂: Exosupur® EV Isolation/Purification Kit

参考文献

原始论文: Separation and Characterization of Heterogeneity Among Various Sizes of Outer Membrane Vesicles Derived from the Probiotic Escherichia coli Nissle 1917 Membranes. 2025. DOI: 10.3390/membranes15050141. PMID/PMCID: 40422751; PMC12113494.