血清外泌体miRNA有助于软脑膜癌病的诊断

核心信息

• 论文英文标题: Serum exosomal miRNA contributes to the diagnosis of leptomeningeal carcinomatosis
• 期刊: J Neurooncol
• 发表年份: 2025
• DOI: 10.1007/s11060-025-04999-x
• PMID/PMCID: 40080246; PMC12106567

研究概览

In this study, serum samples were collected from lung adenocarcinoma patients with LC. And the combination of miRNA-1296-5p, miR-499a-5p and miR-370-3p with CEA can further enhance this potential.

核心发现

The results of miRNA sequencing revealed seven differentially enriched miRNAs (miRNA-1296-5p, miR-503-5p, miR-499a-5p, miR-374a-5p, miR-3173-5p, miR-370-3p and miR-885-3p).

0001), displaying higher diagnostic power for LC.

研究设计

In this study, serum samples were collected from lung adenocarcinoma patients with LC.

The control groups consisted of patients with early-stage and advanced-stage lung adenocarcinoma without LC.

Serum exosomes were isolated for high - throughput RNA sequencing to screen for differential miRNAs, and the results were validated in 123 samples.

Echo Biotech 角色

血清外泌体分离表征&miRNA测序分析

关联平台: Exoomics®, Research Reagents & Tools

关联服务与能力: Biofluid EV Isolation & Purification, EV Basic Characterization (TEM/NTA/WB), EV miRNA Profiling / Sequencing, Research Reagent / Product Supply

关联产品或试剂: Exosupur® EV Isolation/Purification Kit

参考文献

原始论文: Serum exosomal miRNA contributes to the diagnosis of leptomeningeal carcinomatosis Journal of neuro-oncology. 2025. DOI: 10.1007/s11060-025-04999-x. PMID/PMCID: 40080246; PMC12106567.